Adoptive Transfer of Low Zone Tolerance into Normal Adult Mice 1

Summary

Low zone tolerance to BSA in CAF₁ mice appears to be more a specific active immunosuppressive effect than an immunocyte clone-loss phenomenon. Quantities of normal syngeneic splenocytes able to immunologically reconstitute lethally X-irradiated mice failed to break the low zone tolerance, and similar cells obtained from immunized donors did so only partially. Furthermore, spleen cells were able to transfer this tolerance adoptively not only into immunologically deficient X-irradiated recipients but also into immunologically intact normal recipients. These data suggest that this low zone tolerance may be an example of antibody-mediated immunosuppression.