Inhibition of Glucose Oxidation and Fatty Acid Synthesis in Liver Slices from Fed,Fasted and Fasted–Refed Rats by Glucagon,Epinephrine and Cyclic Adenosine-3′,5′-monophosphate

Summary

Glucagon and cyclic adenosine-3′,5′-monophosphate (cAMP) markedly decreased glucose-U-¹⁴C oxidation and conversion into fatty acids in liver slices from fed and fasted–refed rats. Epinephrine was much less effective. Lipogenesis from fasted rats was not reduced by any of these compounds below the level already produced by 2-day fast. The data suggest that hepatic glucagon levels are important in regulating glucose oxidation and its conversion into fatty acids. This effect appears to be mediated via modification of hepatic tissue cAMP levels.