Modulation of the Uptake and Retention of Estradiol-17β in the Ovine Corpus Luteum by Luteinizing Hormone 1

Summary

The uptake and retention of ³H-estradiol by the ovine corpus luteum (induced by superovulation) was maximal through days 8-12 of the cycle with little or no uptake and retention during luteinization or regression. LH, but not FSH or prolactin, inhibited the uptake and retention of estradiol via stimulation of progesterone synthesis.

Progesterone-containing implants were generously provided by Dr. R. E. Mauer, Abbott Laboratories. PMS was generously supplied by the Hormone Distribution Program of NIH and Ayerst Laboratories. HCG-Gonamone was generously supplied by the Fort Dodge Laboratories, Inc. LH, FSH and Prolactin were kindly supplied by the NIH Hormone Distribution Program. Aminoglutethimide was generously supplied by Dr. J. J. Chart, Ciba-Geigy.