Correlation of Dairy Food Intake with Human Antibody to Bovine Milk Xanthine Oxidase 1

Summary

Seventy-three out of 94 human subjects were found to have antibodies to BMXO. Individuals with no BMXO titer had the lowest dairy food consumption of the population tested and there appears to be an inverse relationship between increased dairy fat consumption and decrease in IgA and IgM concentrations in titer groups 1-4. When divided into arbitrary groups according to the geometric mean titer, BMXO titers were higher as the milkfat and whole milk consumption increased (Fig. 1). Multiple regression analysis of the data indicated highly significant correlations (P < 0.0001) between milkshake consumption, milk consumption in early life, abnormal lipoprotein patterns, low serum glucose level and the incidence of tonsillectomy at age 10 or later with the presence of antibodies to BMXO. These correlations and the observation that higher milkfat and whole milk consumption resulted in higher BMXO titers suggest the uptake of dietary BMXO from the gut.