Comparative Toxicity and Protozoacidal Action of Acetarsone,Carbarsone,and Certain Related Pentavalent Arsenical Compounds. 20

Summary

Comparative oral toxicity studies on guinea pigs, rabbits, and cats, and a comparative protozoacidal evaluation on amebae ifzvitro as well as on natural balantidial infestations in guinea pigs and on natural monkey amebiasis indicates that 4-carbamino-phenyl-arsonic acid (“carbarsone”) has definite advantages from the standpoint of application to anti-amebic therapy over acetarsone (“stovarsol”), tryparsamide, “proparsamide,” “iso-butarsamide,” and “n-butarsamide.” It is definitely less toxic on oral administration than these compounds and seems generally more protozoacidal in tolerated doses.