Reaction of Some Rabbit Tissues to Graded Quantities of Trypan Blue

Conclusions

Following the administration of total graded doses of 5 to 100 c.cm. of 1% trypan blue to rabbits, the epithelium of the convoluted renal tubules, of the liver, of the pulmonary alveoli and of the adrenal cortex stored dye in decreasing amounts in the order named. The quantity of dye stored in a given tissue varied with the total quantity of dye administered.

In highly stained rabbits minute amounts of dye were observed also in the bronchiolar epithelium, in the endothelium of the medullary sinusoids of the adrenal and in the mesothelium of the liver, while larger amounts were present in the germinal epithelium of the ovary.