Effects of Increased Metabolism on the Ketone Body Excretion of Depancreatized Dogs. ∗

Summary

The resting metabolism of depancreatized dogs was raised by exercise, by dinitrophenol injection, and by thyroid administration, always, as far as could be learned, at the expense of increased oxidation of fat. Out of the total of 35 series of experiments, none showed increased ketosis commensurate with the increased amounts of fat burned. The quantities of extra acetone to be expected were considerably lower when these were calculated from the basal heat and acetone values rather than from the increased fat oxidation. Even computed in this manner, however, there were only a few of the exercise and thyroid, and none of the D.N.P., results which were in agreement with the theoretical ketone excretion.