Influence of Dinitrophenol on Body Temperature Threshold for Thermal Polypnea. ∗

Conclusion

We may conclude that DNP in doses of 10 and 20 mg per kg, although it does not prevent the occurrence of thermal polypnea, does significantly increase the rectal temperature level at which such polypnea appears. It accordingly appears that DNP does not sensitize the heat defense mechanism as would be required by the second hypothesis stated above. Rather it suggests that DNP depresses both heat and cold defense mechanisms by a nonspecific toxic action.