Influence of AGTH and Cortisone upon Alteration in Capillary Permeability Induced by Hyaluronidase in Rats. ∗

Summary

Intravenous administration of 2000 units of partially purified testicular hyaluronidase in rats induced an increased rate of disappearance of Evans blue, a decreased concentration of serum protein, and an increased hematocrit. These manifestations of an increased capillary permeability due to the action of the enzyme preparation were largely inhibited by 5 days pretreatment with subcutaneous administration (5 mg per day) of either ACTH or cortisone acetate. A minimum of 24 to 48 hours of pretreatment with cortisone acetate was required for a discernible inhibition of the hyaluronidase effect. The evidence suggests an intermediate step between cortisone acetate and its action on connective tissue.