Induction of Regeneration of Forelimb of the Frog by Augmentation of the Nerve Supply. ∗

Summary

The ability of the amputated forelimb of the tadpole to regenerate declines and in most cases is lost completely at the time of metamorphosis. However, .the present report shows that regeneration can be evoked experimentally in the adult frog if the number of nerve fibers available at the amputation surface of the forelimb is augmented by deviation of the sciatic nerve from the hindlimb. The theoretical considerations which led to these experiments emerged from the study of the influence of quantity of nerve fibers in regeneration in salamanders and are discussed here.