Actively and Passively Induced Arthus Reactions in the Mouse. ∗

Summary

1. Arthus reactions were consistently produced in mice 35 days following sensitization by 3 intraperitoneal injections of BPA in an adjuvant. 2. Male and female mice were equally Arthus-susceptible. 3. Hemophilus pertussis organisms did not enhance Arthus sensitivity under the same conditions in which anaphylactic sensitivity is enhanced. 4. Reverse passive Arthus reactions were not detected in mice injected with 0.02 mg rabbit anti-EaN, whereas minimal reactions were produced in guinea pigs with 0.005 mg anti-EaN. 5. Reverse Arthus reactions of minimal severity were produced with 0.06 and 0.005 mg mouse anti-BPA N in mice and guinea pigs, respectively.