RO-1-7780,a Potent Antagonist of Alphaprodine. ∗

Conclusions

(1) 1-3-hydroxy-N-propargyl morphinan has been found a potent antagonist to alphaprodine or morphine in the dog and to alphaprodine in man. (2) Ro-7780 given contemporaneously with alphaprodine at l/75th or 1/100th the dose of the latter appeared to counteract completely the respiratory depression produced in the dog by the narcotic alone. (3) At the same dose ratios of Ro-7780 to alphaprodine in man, the antagonist diminished the severity of the respiratory depression produced by alphaprodine, but otherwise the narcotic effect was judged unaltered.