Nitrogen Sparing Action of Neutral Fat and Fatty Acids in the Phlorhizinized Rat. ∗

Summary

Rats were adapted to the force feeding of a moderate or high carbohydrate or high fat diet for several weeks before phlorhizinization. During the second day of phlorhizin injections, the animals were fed their respective diets, rendered protein free, and the urinary excretions of N.P.N. measured and compared to the outputs of starving animals. The feeding of either neutral fat or carbohydrate reduced N.P.N. losses. A similar sparing of endogenous protein occurred when animals, fed the high fat diet for 3 weeks, were given oleic acid, rather than mazola oil, on the second day of phlorhizinization.