Lessened Insulin Hypophosphatemia Following N-Sulfamlyl-N'-Butylurea (BZ-55 or Carbutamid). ∗

Summary

Insulin tolerance tests in juvenile diabetics following administration of N-sulfanilyl-N'-butylurea (BZ-55 or Carbutamid) failed to show potentiation or prolongation of the usual insulin hypoglycemia and hypophosphatemia. Actually, the decrease in serum inorganic phosphorus which followed administration of insulin to juvenile diabetics was less pronounced, suggesting a diminution in anaerobic glycolysis, either as a result of interference with the usual action of insulin or as a consequence of a decreased glucose load. Both of these possibilities are compatible with decreased gluconeogenesis, increased glycogenation, or diminished glycogenolysis as factors in the decreased insulin requirement which follows administration of this agent to certain patients with diabetes mellitus.