Gastrointestinal Absorption with Oleic Acid-I 131 and L-Methionine-S 35 in Patients with Ulcerative Colitis. ∗

Summary

Following oral administration of oleic acid-I¹³¹ patients with ulcerative colitis showed increased fecal excretion of I¹³¹ during the acute phase of the disease, but it returned toward control values as the patients improved clinically. Following administration of methionine-S³⁵, fecal excretion of S³⁵ increased during the acute phase of the disease to a greater degree than the excretion of I¹³¹. Also, as the patients improved clinically excretion in the feces returned toward control values only slowly, with the result that during the remission stage of the disease excretion of S³⁵ was still elevated and it was elevated in all ulcerative colitis patients studied to date including those with ileostomy and colectomy.