Abstract
Summary
A method is described for determination of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in urine. DMO is not bound to serum albumin. In the dog DMO is excreted completely unchanged in the urine. In the dog and in man the renal clearance of DMO is much higher in alkaline urine than in acid urine. This is explained on the assumption that the compound is reabsorbed in the renal tubule by a process of passive diffusion, the tubular epithelium being permeable to the un-dissociated form and impermeable to the ionic form.
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