Synthesis and antimicrobial activities of pyrano[3,2- c ]quinoline,pyrimido [5′,4′:5,6]pyrano[3,2- c ]quinoline and [1,2,4]triazolo[2″,3″:1′,6′]pyrimido [5′,4′:5,6]pyrano[3,2- c ]quinoline derivatives

The synthesis of novel 7-(4-chlorophenyl)-6-hydroxy-3-methoxy-10-methyl-8,9-dihydro-7H-pyrimido[5′, 4′: 5, 6]pyrano-[3,2-c]quinoline and [1,2,4]triazolo[2″,3″: 1′, 6′]pyrimido[5′, 4′: 5,6]pyrano[3,2-c]quinoline derivatives has been reported. The key intermediate 2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3, 2-c]-quinoline-3-carbonitrile was obtained by treating 4-hydroxy-7-methoxyquinolin-2(1H)-one with various substituted α-cyanocinnamonitrile in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesised compounds.