Simultaneous coexistence of anxiety with depressive disorders is probably one of the major current problems in Medicine. The pharmacological approach for Panic Disorder and Major Depression includes “high-powered” benzodiazepines for the rapid, but transitory relief of same symptoms and especially antidepressant compounds. Recently physical-instrumental approaches have been tested for the treatment of these complex diseases, like Cranial Electrotherapy Stimulation (CES), Trans-cranial Magnetic Stimulation (TMS), and Radio Electric Asymmetric Treatment (REAC). The REAC apparatus was designed to deliver an alternate current of several hundred picoamperes for a time span of 0.5 seconds by means of a small metallic probe directly connected to the properly fabricated electronic circuit in an AC/RF generator with frequency of 2.4, 5.8 or 10.5 GHz and power of 20 mW. Compared the efficacy of REAC and Es-Citalopram in the treatment of simultaneous coexistence of Panic Disorder with Major Depression in 9-weeks open label naturalistic study. After the 1st week, patients treated with REAC therapy showed a significant relief of depressive symptoms compared with Es-Citalopram. For Panic Disorder, REAC treatment had more effective results than the drug especially after the 3rd week of observation. The REAC treatment obtained better results during the entire study, and its high safety and tolerability profile has been confirmed.
BallengerJCFAJ., “Panic disorder and agoraphobia.” DSMIV Sourcebook, ed. W.T.e.al. Vol. 2, Washington DC: American Psychiatric Association. 1996.
2.
BlazerDGKesslerRCMcGonagleKASwartzMS, “The prevalence and distribution of major depression in a national community sample: The National Comorbidity Survey.” The American Journal of Psychiatry, Vol. 151, pp. 979-86, Jul 1994.
3.
AkiskalH. S., “Toward a clinical understanding of the relationship of anxiety and depressive disorder.” Comorbidity of Mood and Anxiety Disorders, ed. Maser JDC.C., Washington, DC: American Psychiatric Press, 1990.
4.
BallengerJCBurrowsGDDuPontRLJrLesserIMNoyesRJrPecknoldJCRifkinASwinsonRP, “Alprazolam in panic disorder and agoraphobia: Results from a multicenter trial. I. Efficacy in short-tenn treatment.” Archives of General Psychiatry, Vol. 45, pp. 413-22, May1988.
5.
DeVaneCLWareMRLydiardRB, “Phannacokinetics, pharmacodynamics, and treatment issues of benzodiazepines: Alprazolam, Adinazolam, and Clonazepam.” Psychopharmacology Bulletin. Vol. 27, pp. 463-73, 1991.
6.
MontgomerySAJudgeR., “Treatment of depression with associated anxiety: Comparisons of tricyclic antidepressants and selective serotonin reuptake inhibitors.” Acta Psychiatrica Scandinayica Supplement Vol. 403, pp. 9-16, 2000.
7.
AltamuraAMannuP., “Disturbo da Attacchi di Panico e trattamento con inibitori selettivi del reuptake della serotonina.” Psicopatologia, Clinica e Terapia, ed. PLS., Vol. II Disturbo Ossessivo-Compulsivo e ii Disturbo da Attacchi di Panico. Roma: Scapicchio PL, 1998.
8.
GonnanJMKentJM., “SSRis and SNRis: Broad spectrum of efficacy beyond major depression.” Journal of Clinical Psychiatry. Vol. 60Suppl 4, pp. 33-8; discussion 39, 1999.
9.
TondoLBurraiCScamonattiLToccafondiFPoddigheAMinnaiGTundoAFlorisG., “Carbamazepine in panic disorder.” The American Journal of Psychiatry. Vol. 146, pp. 558-9, Apr1989.
10.
RinaldiSFontaniV., “Radioelectric Asymmetric Conveyer for therapeutic use.” European Patent Office-World Intellectual Property Organization, October11, 2006, 2000.
11.
BystritskyAKervinLFeusnerJ., “A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder.” Journal of Clinical Psychiatry. Vol. 69, pp. 412-7, 2008.
KirschDSmithR., “Cranial electrotherapy stimulation for anxiety, depression, insomnia, cognitive dysfunction, and pain.” http://www.depressiontreatmentnow.com/bioelectric_medicine.pdf, in Bioelectromagnetic Medicine, a. RoschMSM. Paul J., Ed. Marcel Dekker, Inc., New York, pp. 727-740, 2004.
14.
MarshallFGKirschDL., “Cranial Electrotherapy Stimulation Review: A Safer Alternative to Psychopharmaceuticals in the Treatment of Depression.” http://www.depressiontreatmentnow.com/CES_Review.pdf’, Journal of Neurotherapy. Vol. 9(2), pp. 7-26, 2005.
15.
OmuraY., “Basic Electrical Parameters for Safe and Effective Electro-therapeutics [Electroacupuncture, TES, TENMS (or TEMS), TENS, and Electromagnetic Field Stimulation With or Without Drug FieldJ for Pain, Neuromuscular Skeletal Problems, and Circulatory Disturbances.” Acupuncture and Electro-Therapeutics Research, The International Journal. Vol. 12(3/4), pp. 201-226, 1987.
16.
RoseKMTaylorA. GBourguignonC, “Effects of cranial electrical stimulation on sleep disturbances, depressive symptoms, and caregiving appraisal in spousal caregivers of persons with Alzheimer’s disease.” Applied Nursing Research: ANR. Vol. 22 (2), pp. 119-125, 2009.
17.
BiksonMBulowPStillerJWDattaABattagliaFKamupSVPostolacheTT, “Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage.” Current Treatment Options in Neurology. Vol. 10 (5), pp.377-385, 2008.
18.
RoseKMTaylorAGBourguignonC, “Effects of cranial electrical stimulation on sleep disturbances, depressive symptoms, and caregiving appraisal in spousal caregivers of persons with Alzheimer’s disease” Applied Nursing Research, Vol. 22 (2), pp.119-125, 2009.
KangJIKimCHNamkoongKLeeCIKimSJ, “A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder.” Journal Clinical Psychiatry, 2009.
21.
SimpsonKNWelchMJKozelFADemitrackMANahasZ, “Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis.” Advances in Therapy. 2009.
22.
McLoughlinDM., “Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of major depression.” Evidence-Based Mental Health, 2009.
23.
PallantiSBernardiS., “Neurobiology of repeated transcranial magnetic stimulation in the treatment of anxiety: a critical review.” International Clinical Psychopharmacology, 2009.
24.
RinaldiSFontaniV. “Neuro Psycho Physical Optimization (ONPF) with Conveyer of Modulating Radiance (CMR) therapy. Is it effective in reducing the subjective perception of stress, stress correlated anxiety and depression?” Australian New Zealand Clinical Trials Register, 2001.
25.
RinaldiSFontaniV. “A Randomised controlled trial to evaluate the effectiveness of Neuro Psycho Physical Optimization (NPPO) with Conveyer of Modulating Radiance (CMR Therapy) in reducing the subjective perception of stress and stress-related pains and physical problems.” Australian New Zealand Clinical Trials Register, 2001.
26.
RinaldiSFontaniV. “Neuro-Psycho-Physical Optimization with Conveyer of Modulating Radiance (CMR) in patients with stress-related psychophysiologic sensations. A randomised controlled trial to evaluate the effectiveness.” Australian New Zealand Clinical Trials Register, 2001.
27.
RinaldiSFontaniV. “A Randomised study to evaluate the effectiveness of Neuro Psycho Physical Optimization (NPPO) with Conveyer of Modulating Radiance (CMR Therapy) in reducing the subjective perception of stress, stress-related loss of control and irritability.” Australian New Zealand Clinical Trials Register, 2001.
28.
RinaldiSFontaniV. “A Randomised study to evaluate the effectiveness of Neuro Psycho Physical Optimization (NPPO) with Conveyer of Modulating Radiance (CMR Therapy) in reducing the subjective perception of stress, stress-related physical and mental effort.” Australian New Zealand Clinical Trials Register, 2001.
29.
RinaldiSFontaniV. “A Randomised study to evaluate the effectiveness of Neuro-Psycho Physical Optimization (NPPO) with Conveyer of Modulating Radiance (CMR Therapy) in reducing the subjective perception of stress, stress-related hyperactivity and accelleration.” Australian New Zealand Clinical Trials Register, 2001.
30.
CollodelOMorettiEFontaniVRinaldiSAravagliLSaragoOCapitaniSAnichiniC “Effect of emotional stress on spenn quality.” Indian Journal of Medical Research. Vol. 128, pp. 254-61, Sep 2008.
31.
PeterAValbergTVan DeventerERepacholiMH, “Workgroup Report: Base Stations and Wireless Networks-Radiofrequency (RF) Exposures and Health Consequences.” The Environmental Health Perspective, Vol. 115(3), pp. 416-424, 2007.
32.
APA, Diagnostic and Statistic Manual of Mental Disorders. Vol. IVth edition revised. Washington DC: American Psychiatric Press, 2000.
33.
RinaldiSFontaniV., “Corrections in the functional dysmetrias of the lower limbs and optimization of the static and dynamic postural tone with new method.” Mediterranean Society of Phlebology 2 International Congress, Sousse, Tunisia, 1993.
34.
RinaldiSFontaniVAravagliLBiniS., “Dysmetria and biological stress therapy.” ICMART 2009 - International Congress in Medical Acupuncture and Related Technjgues, Thessaloniki, p. 60, Greece, 2009.
35.
RinaldiSFontaniV. “Evaluation of the effectiveness of the Neuro-Postural Optimization therapy with Conveyer of modulating radiance to treat Functional Dysmetria.” Australian New Zealand Clinical Trials Register, 1997.
36.
RinaldiSFontaniV. “A double blinded randomised trial to evaluate the effectiveness of Neuro-Psycho-Physical Optimimtion (NPPO) with Conveyer of Modulating Radiance (CMR Therapy) in reducing the subjective perception of stress. and stress-related symptoms, assessed with Psychological Stress Measure Test.” Australian New Zealand Clinical Trials Register, 2000.
37.
RinaldiSFontaniVAravagliLBiniS, “Behavioural and stress therapy.” ICMART 2009 - International Congress in Medical Acupuncture and Related Techniques. Thessaloniki, Greece,p.42,2009.
38.
RinaldiSFontaniVAravagliLSaragoO, “CRM Therapy: A new diagnostic and therapeutic approach to the General Adaptation Syndrome.” 1th Congr Men’s Healt Medicine, UNESCO House, W.A.B.T., Paris, 2004.
39.
RinaldiSFontaniVAravagliLSaragoO., “Neuro-Psycho-Physical Optimization with Conveyor of Modulating Radiance. New Strategy to Facilitate Neuro-Psycho-Physical Rehabilitation.” 1st International Congress of Neuroscience for Neuro-Psycho-Physical Optimization. UNESCO House, I.S.N.P.O., Paris, 2005.
40.
HamiltonM., “A rating scale for depression.” Journal of Neurology. Neurosurgery & Psychiatry. Vol. 23, pp. 56-62, 1960.
