Abstract
Chromosome 6q22–27 harbors risk genes for kidney disease. We evaluated 1,434 individuals with glomerulonephritis (cases) and 603 unaffected individuals (controls) for RAET1 genes at 6q22–27 using samples from the Medical Research Council/Kidney Research UK Glomerulonephritis DNA bank in a 2-stage approach. Top ranked single nucleotide polymorphisms were also geno-typed in kidney transplant recipients (n=571) and their respective donors (n=520) as controls to evaluate association with end-stage renal disease (ESRD). Provisional data suggested that rs9397070 in the RAET1G gene was associated with susceptibility to glomerulonephritis [Odds ratio (OR) 1.24, 95%; confidence interval (CI): 1.01–1.54, P=0.04] and further supported by additional genotyping (OR 1.22, 95% CI: 1.03–1.42, P=0.02). Genotyping the renal transplant population did not identify any significant association with ESRD. The RAET1 gene family contains candidate genes for kidney disease; however, common RAET1 gene polymorphisms are not identified as strong genetic risk factors for glomerulonephritis in these white populations.