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Client-Centered Activities of Daily Living Intervention (CADL)
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| One level 1B study provides low strength of evidence to support client-centered goal setting and collaboration interventions to address IADL performance and participation for people ≤3 months after stroke onset. |
Bertilsson et al. (2014)
Level 1B—RCT
RoB
Low
Country
Sweden
Setting
Inpatient Outpatient Home-based rehabilitation |
Population
N = 280, >3 mo poststroke
Intervention group:
Mean age: 74 yr; Gender percentage: 57% men and 43% women
Control group:
Mean age: 71 yr; Gender percentage: 63% men and 37% women
Intervention
CADL (n = 129). The CADL intervention integrated the principles of client-centered practice and the person’s unique lived experiences for goal setting and collaboration during the rehabilitation process.
Control
UADL (n = 151)
Dosage
The number of OT sessions was not limited or decided in advance for either group. |
No statistically significant differences were noted between groups on IADL outcomes. |
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Driving Simulation
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| There was one level 1B study that provided moderate strength of evidence to support the use of driving simulation to improve driving performance up to 6 months post intervention. There was one level 2B study that was a follow up to the first study that provided low strength of evidence to support the use of either driving simulation or cognitive training to improve driving performance 5 years post intervention. |
Devos et al. (2009)
(6 mo poststroke) Level 1B
RoB
Low
Country
Belgium
Setting
Rehabilitation unit |
Participants
N = 83 (attrition: 10 during intervention, 21 at 6-mo follow-up). First-ever subacute stroke patients, >75 yr old, had a valid driver’s license, and had a history of active driving before stroke onset were included
Mean age: 54 yr; Gender: 81% men and 19% women
Intervention group
(n = 42), Simulator-based driving training. Trained in a stationary full-bodied Ford Fiesta 1.8 with automatic gear transmission and all its original mechanical parts. Life-size computer-generated images were projected on a flat screen with a horizontal visual angle of 45°. Tailor-made, interactive driving scenarios were developed using the “Scenario Definition Language” from STISIM Drive System (version 1.03; Systems Technology Inc, Hawthorne, CA).
Control
(n = 41), Cognitive training—Participants were trained on problem-solving skills, visuospatial skills, planning, memory training, road sign recognition, and route finding using off-the-shelf games.
Dosage
Fifteen training sessions of 1 hr at a rate of three sessions/week (5 wk total) |
On-road driving performance was assessed before, immediately after training, and at 6 mo poststroke. Between groups, the intervention group that received driving simulator training had significantly better results when compared with the cognitive training group in the overall on-road score: posttraining (β = 0.372; 95% CI = 0.162–0.550; p = 0.02) and at 6-mo follow-up (β = 0.531; 95% CI = 0.151–0.911; p = 0.006), and the items of anticipation and perception of signs (β = 0.668, 95% CI = 0.269–1.068, p = 0.001), visual behavior and communication (β = 0.725, 95% CI = 0.279–1.172, p = 0.002), quality of traffic participation, and turning left (β = 0.664, 95% CI = 0.226–1.101, p = 0.002). |
Devos et al. (2010)
Level 2B—5-yr follow-up assessment of participants from 2009 study
RoB
Low
Country
Belgium
Setting
Outpatient clinic |
Participants
N = 44 at follow-up, chronic stage, 5-yr postintervention In the 5-yr follow-up article, 61 participants were reassessed. Forty-four participants (simulator group, n = 21; cognitive group, n = 23) completed all assessments.
Intervention group
Mean age: 58 yr; Gender: 22 males and 8 females
Control group
Mean age: 59 yr; Gender: 27 males and 4 females
Intervention
See above
Control
See above
Dosage
See above |
No statistically significant results were reported using the Fitness to drive and Current Driving Status as outcome measures at 5-yr postdriving simulation intervention and cognitive intervention. Results did not last for either type of intervention. |
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Medication Management
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| There are two articles, one level 1B and one level 2B, that provide moderate strength of evidence that interventions focused on medication management improve individuals’ IADL performance. |
Kamal et al. (2015)
Level 1B—Parallel-group, assessor-blinded, RCT
RoB
Low
Country
Pakistan
Setting
Neurology and Stroke Clinics at Tertiary Care Center |
Participants
N = 200 18 yr or older; >1 mo since the last episode of stroke; possession of a personal cell phone that the patient always has access to.
Intervention group
Mean age: 56 yr; Gender: 67.5% (135) male and 32.5% (65) female
Control group
Mean age: 57.6 yr; Gender: 67.5% (135) male and 32.5% (65) female
Intervention
(n = 100), Medication management: In addition to usual care, this group received SMS reminders customized to their individual prescription. The participants were required to respond to the SMS stating if they have taken their medicines. Moreover, twice weekly health information SMS were also sent to the intervention group. The research team customized the health information SMS according to medical and drug profile of every patient.
Control
(n = 100), Standard of care as per institutional guidelines. This primarily consists of regular follow-up visits (as advised by their neurologist) with their stroke neurologist and emergency contact number.
Dosage
The intervention group received an SMS text reminder for every medication dose, as well as twice weekly health information SMS texts. Both groups also received standard care. |
Medication adherence increased in both groups. Although the increase was minor, the difference was found to be a statistically significant better medication adherence in the intervention group. Multivariable analysis showed that the mean difference in adherence score between the intervention group and the usual care group was 0.54 (95% CI = 0.22–0.85, p ≤ .01) adjusted for all other variables. |
O’Carroll et al. (2013)
Level 2B—Pilot RCT
RoB
Low
Country
Scotland
Setting
Participants’ homes |
Participants
N = 62. First stroke and discharged home
Intervention group
Mean age: 69 yr; Gender: 69% male
Control group
Mean age: 71 yr; Gender: 59% male
Intervention
(n = 29), Two-session intervention aimed at increasing adherence via (a) introducing a plan linked to environmental cues (implementation intentions) to help establish a better medication-taking routine (habit) and (b) eliciting and modifying any mistaken patient beliefs regarding medication/stroke.
Control
(n = 29), Participants received the same number of visits by the research fellow, and all measures including BP readings were collected at the same time points as the intervention group. During the first two sessions, the research fellow engaged the patient in nonmedication-related conversation to control for nonspecific effects of attention/social contact.
Dosage
Two brief sessions, 2 wk apart (no further details reported) |
Electronically recorded openings using Medication Events Monitoring System (MEMS(R) Aardex Ltd., Switzerland) pill bottles for 3 mo calculated the percentage of (a) prescribed doses taken, (b) days on which the correct dose was taken, and (c) doses taken on schedule, that is, within a 3-hr window of the median time taken. The intervention group had significantly higher adherence on all three MEMS outcome measures than the control group, although this was only significant for doses taken on schedule (i.e., percentage of doses taken on schedule: mean difference, 9.8%; 95% CI = 0.2–16.2; p = 0.048; percentage of total doses taken: mean difference, 5.1%; 95% CI = −1.6 to 9.0; percentage of days correct dose taken: mean difference, 5.4%; 95% CI = −1.8 to 9.4. There were significant time and interaction effects of total Medication Adherence Report Scale (MARS) scores, with both groups reporting higher adherence at follow-up, but a significantly greater improvement in the intervention group (mean difference, 0.61; 95% CI = 0.1–1.2; p = 0.027). |
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Constraint-Induced Therapy (CIT)—With or Without Additional Interventions
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| Four articles, two level 1B and two level 2B, provided strong strength of evidence to support the use of CIT, with or without trunk restraint, robotic therapy, and self-regulation, to improve IADL performance and participation after stroke. |
Liu et al. (2016)
Level 1B—RCT
RoB
Low
Country
China
Setting
Inpatient rehabilitation |
Participants
N = 86. Stroke onset less than 3 mo were aged above 60 and had at least 10° of active metacarpophalangeal joint and interphalangeal joint extension, 20° of active wrist extension.
Mean ages:
Control group: 67.87 yr; mCIMT group: 65.07 yr; SR and mCIMT: 66.80 yr
Gender %male: Control group: 50%; mCIMT group: 74.2%; SR-mCIMT: 48.3%
Intervention 1
(n = 31), mCIMT: restraint of the nonimpaired limb for 4 hr/day; therapist provided demonstration on the adapted task performance with one arm (the side of the patient’s hemiplegic arm), and this was followed by the patient’s supervised practice using the hemiplegic arm.
Intervention 2
(n = 29), SR and-mCIMT: restraint of the nonimpaired limb for 4 hr/day but instead of demonstration and practice protocols patients were taught to use the SR strategy (i.e., self-reflection on abilities and deficits in task performance, identifying problems and solutions and practice of the adapted tasks.
Control
(n = 26), Conventional functional rehabilitation—therapist demonstrated the adapted task performance, and this was followed by the patient’s supervised practice using both arms.
Dosage
Ten 1-hr therapist-guided training sessions administered over 2 wk. Participants learned 10 daily tasks (five per week) |
Between-group differences on the Lawton IADL scale showed significant improvement in the SR-mCIMT group over both the mCIMT and control groups postintervention (p = 0.001). |
Wu et al. (2012)
Level 1B—single-blind RCT
RoB
Low
Country
Taiwan
Setting
Rehabilitation hospitals |
Participants
N = 57. >6 mo after ischemic or hemorrhagic stroke
Mean age:
dCIT-TR group: 54.0 yr; dCIT group: 56.3 yr; Control group: 58.6 yr
Gender % Female:
dCIT-TR group: 20.0%; dCIT group: 26.3%; Control group: 22.2%
Intervention 1
dCIT with TR group: (n = 20) training of the affected UE included shaping skills and repetitive practice of functional tasks; TR harness secured the trunk to the back of the chair; unaffected hand was restrained in a mitt for 6 hr per day for 3 wk
Intervention 2
dCIT group: (n = 19) same invention as dCIT-TR group minus TR.
Control group
(n = 18) usual and customary care
Dosage
All treatments were dose matched (2 hr per day, 5 days per week, for 3 wk). |
The dCIT-TR (p = 0.01) and dCIT (p = 0.04) groups exhibited significantly higher functional activity scores as compared with the control group; the dCIT-TR group (p = 0.01) had a significantly higher frequency of participation in outdoor activities as compared with the control group. |
Hsieh et al. (2016) Level 2B—RCT
RoB
Low
Country
Taiwan
Setting
Hospital |
Participants
N = 34, chronic unilateral stroke (>6 mo poststroke), able to perform ≥10° of wrist extension with extension of at least two fingers >0° and <10° and with thumb abduction ≥10°, without excessive spasticity in any of the UE joint
Intervention/RT + mCIT: n = 17
Mean age = 55.1 yr; Gender: 35% women
Control/RT: n = 17
Mean age = 68 yr; Gender: 24% women
Intervention
(n = 17), RT + mCIT: For the first 2 wk, participants in RT + mCIT group received RT, using the same treatment principles as those in the RT group (see below). RT was followed by 2 wk of a form of mCIT with reduced training and restraint time compared with the original CIT. Treatment components included repetitive training of the affected UE in functional tasks with behavior shaping. A mitt was used to restrict the unaffected hand for 6 hr each day. Some strategies of transfer package applied to facilitate the use of the affected UE included behavioral contract, home diary, and problem-solving mentoring
Control/RT
(n = 17), Participants in the RT group used the Bi-Manu-Track to perform movements of forearm pronation–supination and wrist flexion–extension, with three computer-controlled modes (passive/passive, active/passive, active/active).
Dosage
Both groups received a similar amount of therapy time (an average of 90 to 105 min/day, 5 days for 4 consecutive weeks). |
RT + mCIT significantly improved independence in IADL as compared with RT control p = 0.02. |
Lin et al. (2009)
Level 2B—RCT
RoB
Low
Country
Taiwan
Setting
Rehabilitation |
Participants
N = 32. Brunnstrom stage III or better for the proximal part of the affected upper limb;
Intervention (CIT) (n = 16)
Mean age: 54 yr; Gender: 69% male
Control (n = 16)
Mean age: 57 yr; Gender: 69% male
CIT group
(n = 16), Included functional training of the affected limb. Shaping, adaptive, and repetitive practice of functional tasks included dialing a phone number, reaching forward to move a jar from one place to another, picking up a cup and drinking from it, and other activities like those performed daily.
Control group
(n = 16), NDT emphasizes functional task practice when possible, as well as weight bearing by the affected limb and fine motor dexterity activities. This also included compensatory techniques using the less affected limb to perform functional tasks and assist the affected limb during task performance
Dosage
2-hr therapy sessions, 5 times per week for 3 wk.
Note: Subjects from both groups were required to place their less-affected hands and wrist in mitts with Velcro straps when not in therapy while in the natural environment |
Significant improvement in mobility in the intervention group (p = 0.007) over the control group. |
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Predischarge Home Visit with an OT
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| There is one level 2B article that provided low strength of evidence to support a pre-discharge home visit with an OT to improve IADL performance. |
Drummond et al. (2013)
Level 2B—Feasibility RCT and cohort study
RoB
Low
Country
United Kingdom
Setting
Rehabilitation |
Participants
N = 126, RCT: eligible participants for randomization were those for whom the multidisciplinary team felt there was clinical uncertainty about whether a home visit was indicated. Cohort study: participants for whom the team believed a home visit was essential.
RCT
n = 93
Intervention group
Mean age: 70 yr; Gender: 55% men and 45% women
Control group:
Mean age: 73.65 yr; Gender: 52% men and 48% women
Cohort study
n = 33
Mean age: 71 yr; Gender: 45% men and 55% women
Intervention
(n = 47), Home visit-Predischarge home visit with an OT. Patients were assessed in their own home and any potential problems were discussed and addressed in the home environment. On the visit, patients were offered advice, given practice in transfers and ADLs, and offered equipment or adaptations, such as grab rails.
Control
(n = 46), No home visit. Received a predischarge home assessment structured interview with an OT in the hospital. The patient’s discharge and any potential problems were discussed in general terms.
Cohort study
(n = 33), Received a home visit using the same protocol as those in the RCT group.
Dosage
One home visit or one in patient interview/educational session. |
No significant results on IADL performance |
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Occupational Therapy and Mental Practice
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| There is one level 2B article that provided low strength of evidence to support mental practice intervention to improve IADL performance. |
Nilsen et al. (2012)
Level 2B—single-blind, RCT over an 18-mo period
RoB
Moderate
Country
United States
Setting
Clinic Home-based |
Participants
N = 19 participants—2 completed (1 internal and 1 external group). Minimum 9-wk post onset; 18 to 90 yr old; cognitively intact; able to actively flex the affected wrist and metacarpophalangeal and interphalangeal joints of two digits of the hand a minimum of 10 degrees of neutral
Gender:
Control: 50% female; Internal group: 40% female; External group: 50% female
Mean age:
Control: 66 yr; Internal group: 47 yr; External group: 62 yr
Intervention (1)
Internal group: n = 6/1; occupational therapy + MP from the internal perspective (i.e., first person—clients imagine performing the movements from the perspective of being inside their own body; thus, they imagine looking through their own eyes when performing the movements)
Intervention (2)
External group: n = 7/1; occupational therapy + MP from the external perspective (i.e., third person-clients imagine performing the movements from the perspective of being outside their body; thus, they imagine being an observer of themselves in motion)
Note for both intervention groups: In the MP training sessions, participants listened to an audiotaped script that facilitated the generation of various imagery modalities (i.e., visual, kinesthetic) design to simulate the environment in which task performance would take place and the motions that would be generated during overt practice.
Control
n = 6/0 occupational therapy + relaxation imagery
Dosage
Participants received 30-min sessions of occupational therapy 2×/week for 6 wk. |
No statistically significant results. |