Markov
Research article
Offline fitting Markov switching model
M.B. Malyutov
Abstract
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Markov
In this paper, we present a new continuous time model for nonstationary correlation structures for longitudinal data. This model, which provides a continuous time analogue to the antedependence model and is thus referred to as the continuous antedependence (CAD) model, is intended to provide more refined correlation models for longitudinal data and to better accommodate sparse (or highly unbalanced) data. A key component of this model is the ‘nonstationarity function’ which describes nonstationarity as a unidimensional function of time and has an interesting time expansion/contraction interpretation. Focusing on a Markovian version of the model, we develop a novel nonlinear regression model providing nonlinear least square estimators of model parameters. Both unstructured (for nonparametric estimation) and structured versions of the model are presented. We apply the proposed approach to data from the Multicenter AIDS Clinical Study (MACS), with a focus on inference for the nonstationarity function. In simulation studies, we show good properties (low finite sample bias, and high convergence rates and efficiency) of the proposed unstructured model estimator, which compare favorably to those of an alternative maximum likelihood estimator, particularly in sparse data situations.
The
One of the main characteristics of data from survival analysis is that the random variable of interest is not always observed, so that some observations are censored. The usual methods consider that these observations do not carry information about the distribution of the response variable (non-informative censoring). In other words, it is considered that an observation is censored simply by the fact that the event of interest (failure or death) did not occur during the period of study. However, in many situations, the survival time is clearly perturbed by the censoring mechanism, so the effect produced must be included in the analysis. The question is that once informative censoring is assumed to be non-informative, the results of the analysis can mask biases and thus weakening the model’s predictive power. Therefore, we consider the informative censoring mechanism in the odd-logistic Weibull regression model, based on the method described in Huang and Wolfe (2002), to analyze the variations which occur for estimating the model parameters. We obtain maximum likelihood estimates of the parameters by considering censored data and evaluate local influence on the estimates for different perturbation schemes. In addition, we define martingale and deviance residuals to detect outliers and evaluate the model assumptions. We show that the proposed regression model is useful to the analysis of real data and may give more realistic fits than other special regression models.
In this paper it is introduced a new two-parameter discrete distribution derived from the continuous Sushila distribution (Shanker et al., 2013). Its mathematical properties and estimation procedures for the parameters of the proposed model are presented assuming complete and right-censored data. This new model, in the same way as the continuous Sushila distribution, has the discrete Lindley distribution as a special case. An extensive simulation study is carried out to examine the bias and the roots of the mean squared errors for the maximum likelihood estimators as well the moments and Bayesian estimators of the proposed model parameters. Some examples using simulated data and real datasets are considered to show that the new proposed model performs at least as good as its particular case and some other traditional discrete models as the Poisson and geometric distributions.
In sampling from finite populations to estimate the finite population mean/total of the study variable, one often observes available information on an associated auxiliary variable along with study variable to obtain an estimator, which is more efficient than the simple mean per unit estimator based on observations on study variable only. The classical ratio estimator is one such estimator, which is simple to compute and is more efficient than the simple mean per unit estimator under certain conditions. However, the ratio estimator in spite of its simplicity is a biased estimator having bias of