Breast Disease: All articles

Breast Disease: All articles

All articles

1-20 of 718 articles

Sort by:

Select all

Sort by:

Introduction
Free accessIntroductionFirst published June 1, 2002pp. 1-2
Introduction
Stan Lipkowitz
Editorial
Free accessEditorialFirst published August 1, 1998pp. 1-1
Foreword
Edison T. Lui
Editorial
Free accessEditorialFirst published April 1, 1998pp. 1-1
Foreword
Richard Klausner
Editorial
Free accessEditorialFirst published September 27, 2009pp. 1-1
Editorial
Bernhard C. Pestalozzi
Introduction
Free accessIntroductionFirst published October 31, 2008pp. 1-1
Introduction
Barbara K. VonderhaarGilbert H. Smith
Introduction
Free accessIntroductionFirst published April 12, 2007pp. 1-2
Introduction to Breast Disease Review Issue on Metastasis
Lalage WakefieldKent Hunter
Case report
Free accessCase reportFirst published June 27, 2017pp. 1-6
Expression of TTF-1 in breast cancer independently of ER expression: A case report and pathogenic implications
Ioannis A. VoutsadakisPaul Mozarowski
Abstract
Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity. Additionally, a PTEN mutation was present on genomic evaluation of the primary tumor. Diagnostic, pathogenic and therapeutic implications of these findings are discussed.
Brief report
Free accessBrief reportFirst published November 5, 2021pp. 1-3
New safer management for breast cancer patients who need neoadjuvant therapy during SARS-COVID pandemic
Donato CasellaDaniele FusarioAlessandro Neri
Abstract
During the first hit of SARS-COVID pandemic, an important reorganization of Healthcare Services has been done, and new protocols and pathways to protect frail patients like oncological patients were designed. The second hit of pandemic had stressed these new pathways and suggests to health-workers some improvements for safer management of patents.

We reported our experience in organizing the clinical pathway of neoadjuvant therapy candidate patients based on the execution of sentinel lympho-node biopsy and the placement of implantable venous access port in the same access to operating room before neoadjuvant chemotherapy suggesting a possible organizational model. In the period October–December 2020 we have included in this new type of path twelve patients and we have not registered any cases of COVID among the patients included. We think this new path, adopted amid the second hit, will be useful for all Breast Units that are facing the challenge of guaranteeing the highest standards of care in a historical moment where the health emergency occupies the efforts of health workers and the economic resources of health systems.
Introduction
Free accessIntroductionFirst published November 24, 2004pp. 1-1
Introduction
Wei-Zen Wei
Research article
Free accessResearch articleFirst published June 27, 2017pp. 1-6
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in non-metastatic breast cancer patients from a Hispanic population
Allan Ramos-EsquivelLuis Rodriguez-PorrasJuan Porras
Abstract
BACKGROUND:
High values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been associated with poor prognosis in certain tumors. Nevertheless, few data exist regarding these prognostic variables in breast cancer patients from Hispanic populations. In this study, we aimed to determine the prognostic value of these two estimates and to establish the best cutoff to categorize patients according to their risk.
MATERIALS AND METHODS:
We retrospectively reviewed 172 consecutive breast cancer patients treated in our center. Pre-treatment NLR and PLR, as well as clinical variables were collected from medical records. Univariate and multivariate Cox regression analyses were performed to assess the relationship between NLR, PLR, overall survival (OS) and disease free survival (DFS), adjusted for potential confounders. The best cut-off point was determined based on the maximization of the Log-rank test statistic.
RESULTS:
Median follow-up time was 71.3 months. The optimal cut-off for NLR and PLR was 3 and 250, respectively. In univariate analysis, a NLR 3 was associated with poor DFS (Hazard Ratio (HR): 3.92; 95% Confidence Interval (CI): 1.98–7.77; p < 0.001) and reduced OS (HR: 4.20; 95% CI: 2.10–8.38; p < 0.001). Similarly, a PLR 250 was associated with worse DFS (HR: 5.01; 95% CI: 2.33–11.1; p < 0.001) and poorer OS (HR: 5.35; 95% CI: 2.43–11.76; p < 0.001). However, after adjustment for potential confounders, only the PLR was independently associated with worse outcomes.
CONCLUSIONS:
A NLR greater than 3 and a PLR greater than 250 were associated with worse OS and DFS in Hispanic patients with breast cancer.
Introduction
Free accessIntroductionFirst published June 1, 2003pp. 1-2
Introduction
Douglas Yee
Introduction
Free accessIntroductionFirst published April 11, 2006pp. 1-1
Inflammatory Breast Cancer
Sandra M. Swain
Editorial
Free accessEditorialFirst published June 23, 2006pp. 1-2
A Comprehensive Review of Breast Cancer in Young Women
Nancy Klauber-DeMore
Introduction
Free accessIntroductionFirst published December 1, 2004pp. 1-1
Introduction
Kathy Miller
Review article
Free accessReview articleFirst published March 15, 2011pp. 1-8
Surgically placed wound catheters (SPWC) and local anaesthetic infusion in breast surgery: Efficacy and safety analysis
G.K.G. RaghavendraR.H. SreenivasaK. Ashok
View All
Abstract
Background:
The effectiveness of surgically placed wound catheters (SPWC) and local anaesthetic infusion in the management of post-operative pain following breast surgery is controversial. This meta-analysis was performed to assess efficacy SPWC compared to other techniques of pain management.
Material and methods:
The meta-analysis included randomised control trials that compared SPWC with other forms of pain control. Post-operative opioid requirements and pain measured in visual analogue scale (VAS) were analysed using Comprehensive Meta-analysis Software version 2. Literature was reviewed for the safety of the SPWC and local anaesthetic infusion.
Results:
Four randomised controlled trials evaluating 147 women were included in the final analysis. The overall standard difference in means was 0.094 and 0.033 for post-operative opioid requirement and pain respectively favouring the SPWC and local anaesthetic infusion group. It is a safe technique with no major adverse events as a result.
Conclusion:
Surgically placed wound catheters and local anaesthetic infusion is clinically safe in a wide range of surgical procedures on the breast and there appears to be a trend towards improved post operative pain relief. The studies analyzed in this review have several important drawbacks such as inadequate power to detect significant differences (none of them included more than 50 patients). A well designed RCT of patients undergoing breast surgery with an adequate number is of patients required to emphatically demonstrate if the operative site infusion with local anaesthetic solution postoperatively is safe and efficacious compared to opioid based regimens alone for post operative pain relief.
Review article
Free accessReview articleFirst published April 26, 2021pp. 1-16
Breast cancer radiotherapy: What physicians need to know in the era of the precision medicine
Ana Aurora Díaz-GavelaElia del Cerro PeñalverSofía Sanchez García
View All
Abstract
Breast cancer is the most common cancer in women worldwide and encompasses a broad spectrum of diseases in one with significant epidemiological, clinical, and biological heterogeneity, which determines a different natural history and prognostic profile. Although classical tumour staging (TNM) still provides valuable information, the current reality is that the clinicians must consider other biological and molecular factors that directly influence treatment decision-making. The management of breast cancer has changed radically in the last 15 years due to significant advances in our understanding of these tumours. This knowledge has brought with it a major impact regarding surgical and systemic management and has been practice-changing, but it has also created significant uncertainties regarding how best integrate the radiotherapy treatment into the therapeutic scheme. In parallel, radiotherapy itself has also experienced major advances, new radiobiological concepts have emerged, and genomic data and other patient-specific factors must now be integrated into individualised treatment approaches. In this context, “precision medicine” seeks to provide an answer to these open questions and uncertainties. The aim of the present review is to clarify the meaning of this term and to critically evaluate its role and impact on contemporary breast cancer radiotherapy.
Research article
Free accessResearch articleFirst published May 21, 2010pp. 1-5
Wound Complications from Surgery in Pregnancy-Associated Breast Cancer (PABC) 1
Laura S. DominiciHenry M. KuererGildy Babiera
View All
Abstract
Background:
There are concerns that physiologic changes of the peripartum breast may result in complications in breast conservation therapy. We present the complications of breast conservation surgeries and mastectomies performed for pregnancy-associated breast cancer (PABC).
Materials and methods:
From April 1989 through April 2008, sixty-seven breast cancer patients underwent surgical management for PABC, defined as surgery during pregnancy or within one year postpartum. Records of women who had surgery were examined for post-operative wound complications of milk fistula, cellulitis, abscess, or hematoma.
Results:
Forty-seven patients underwent mastectomy. Twenty were treated with conservative breast surgery. There were six complications, all treated in the outpatient setting. There were no documented milk fistulae.
Conclusions:
In our series, we had few postoperative complications and no milk fistulae for those patients undergoing surgery for PABC. When compared to those who had mastectomy for PABC, women who underwent breast conserving therapy did not appear to have increased frequency of surgical complications.
Introduction
Free accessIntroductionFirst published December 1, 1998pp. 1-2
Introduction
Jane Reese-Coulbourne
Introduction
Free accessIntroductionFirst published June 1, 2000pp. 1-3
Introduction
Yosef Yarden
Introduction
Free accessIntroductionFirst published August 1, 2001pp. 1-1
Introduction
Etta D. Pisano