Association Between Abnormal Uterine Artery Doppler Flow Velocimetry,Risk of Preeclampsia,and Indices of Arterial Structure and Function: A Pilot Study
Available accessOtherFirst published online August, 2008
Association Between Abnormal Uterine Artery Doppler Flow Velocimetry,Risk of Preeclampsia,and Indices of Arterial Structure and Function: A Pilot Study
Preeclampsia increases the risk of future cardiovascular disease. The association between abnormal uterine artery Doppler flow velocimetry, risk of preeclampsia, and indices of arterial structure and function is investigated in this study. The carotid intima-media thickness of 34 pregnant women with normal uteroplacental flow was compared with 30 women with abnormal uterine artery Doppler analysis during the transvaginal assessment of the uterine arteries at the routine anomaly scan (20-23 weeks of gestation). Women with abnormal uterine artery Doppler results had a greater mean internal (but not common) carotid intima-media thickness (0.58 ± 0.06 vs 0.53 ± 0.08, respectively, P = .005) and risk of developing preeclampsia (6 of 30 vs 0 of 34 or 20% vs 0%, respectively, P = .0079) compared with those with normal uteroplacental flow. Women with abnormal uterine artery Doppler results may be at increased risk not only for developing subsequent preeclampsia but also for future cardiovascular disease.
Bellamy L., Casas JP, Hingorani AD, et al. Pre-eclampsia and risk of cardiovascular disease and cancer later in life: systematic review and meta-analysis. BMJ. 2007;335:974.
2.
Blaauw J., van Pampus MG, Van Doormaal J., et al. Increased intima-media thickness after early-onset preeclampsia . Obstet Gynecol. 2006;107:1345-1351.
3.
Kanadasi M., Cayli M., San M., et al. The presence of a calcific plaque in the common carotid artery as a predictor of coronary atherosclerosis. Angiology. 2006;57:585-592.
4.
Bots MLCarotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies. Curr Med Res Opin. 2006;22:2243-2250.
5.
Paraskevas KI , Hamilton G., Mikhailidis DPStatins: an essential component in the management of carotid artery disease. J Vasc Surg. 2007 ;46:373-386.
6.
Cheng KS, Mikhailidis DP, Hamilton G., et al. A review of the carotid and femoral intima-media thickness as an indicator of the presence of peripheral vascular disease and cardiovascular risk factors. Cardiovasc Res. 2002;54:528-538.
7.
Stone PHEvaluating cardiovascular pathophysiology and anatomy in atherosclerosis. Am Heart Hosp J. 2005; 3:187-192.
8.
Moens AL, Goovaerts I., Claeys MJ, et al. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool?Chest. 2005;127:2254-2263.
9.
Garcia RG, Celedon J., Sierra-Laguado J., et al. Raised C-reactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia. Am J Hypertens. 2007;20:98-103.
10.
Takase B., Goto T., Hamabe A., et al. Flow-mediated dilation in brachial artery in the second half of pregnancy and prediction of pre-eclampsia. J Hum Hypertens . 2003;17:697-704.
11.
Tihtonen KM , Koobi T., Uotila JTArterial stiffness in preeclamptic and chronic hypertensive pregnancies. Eur J Obstet Gynecol Reprod Biol . 2006;128:180-186.
12.
Oyama-Kato M., Ohmichi M., Takahashi K., et al. Change in pulse wave velocity throughout normal pregnancy and its value in predicting pregnancy-induced hypertension: a longitudinal study. Am J Obstet Gynecol. 2006;195:464-469.
13.
Papageorghiou AT, Leslie K.Uterine artery Doppler in the prediction of adverse pregnancy outcome. Curr Opin Obstet Gynecol. 2007;19:103-109.
14.
Espinoza J. , Romero R., Nien JK, et al. Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor. Am J Obstet Gynecol. 2007;196:326.e1-e13.
15.
Papageorghiou AT, Yu CK, Nicolaides KHThe role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol . 2004;18:383-396.
16.
Rich-Edwards JW, Manson JE, Hennekens CH, et al. The primary prevention of coronary heart disease in women. N Engl J Med. 1995 ;332:1758-1766.
17.
Papageorgiou AT, Yu CK, Bindra R., et al. Fetal medicine foundation second trimester screening group. Multi-center screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation . Ultrasound Obstet Gynecol.2001;18:441-449.
18.
Karatzis E. , Lekakis J., Papamichael C., et al. Rapid effect of pravastatin on endothelial function and lipid peroxidation in unstable angina. Int J Cardiol. 2005;101: 65-70.
19.
Papalambros E. , Sigala F., Georgopoulos S., et al. Malondialdehyde as an indicator of oxidative stress during abdominal aortic aneurysm repair. Angiology. 2007; 58:477-482.
20.
Davey DA, MacGillivray I.The classification and definition of the hypertensive disorders of pregnancy . Am J Obstet Gynecol. 1988;158:892-898.
21.
Gardose J., Mongelli M., Wilcox M., et al. An adjustable fetal weight standard. Ultrasound Obstet Gynecol. 1995;6:168-174.
22.
Stamatelopoulos KS, Lekakis JP, Poulakaki NA, et al. Tamoxifen improves endothelial function and reduces carotid intima-media thickness in postmenopausal women. Am Heart J. 2004;147:1093-1099.
23.
Stamatelopoulos KS, Kalpakos D., Protogerou AD, et al. The combined effect of augmentation index and carotid intima-media thickness on cardiovascular risk in young and middle-aged men without cardiovascular disease. J Hum Hypertens . 2006;20:273-279.
24.
Corretti MC , Anderson TJ, Benjamin EJ, et al; International Brachial Artery Reactivity Task Force.Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force . J Am Coll Cardiol. 2002;39: 257-265.
25.
Asmar R., Benetos A., Topouchian J., et al. Assessment of arterial distensibility by automatic pulsewave velocity measurement. Validation and clinical application studies. Hypertension. 1995;26:485-490.
26.
Kusuoka H., Hoffman JLAdvice on statistical analysis for Circulation Research. Circ Res. 2002;91:662-671.
27.
World Health Organization Collaboration.The world health report 2005-make every mother and child count. http://www.who.int/whr/2005/en. Accessed December 2, 2007.
28.
Savvidou MD , Hingorani AD, Tsikas D., et al. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet. 2003;361:1511-1517.
29.
Sharma JB, Sharma A., Bahadur A., et al. Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet. 2006;94:23-27.
30.
Chamy VM, Lepe J., Catalan A., et al. Oxidative stress is closely related to clinical severity of pre-eclampsia. Biol Res. 2006;39:229-236.
31.
Karowicz-Bilinska A., Kedziora-Kornatowska K., Bartosz G.Indices of oxidative stress in pregnancy with fetal growth restriction. Free Radic Res. 2007;41:870-873.
32.
Rudra CB, Qui C., David RM, et al. A prospective study of early-pregnancy plasma malondialdehyde concentration and risk of preeclampsia. Clin Biochem. 2006;39:722-726.
33.
Rojas A., Figueroa H., Morales MA, et al. Facing up the ROS labyrinth-Where to go? Curr Vasc Pharmacol. 2006;4:277-289.
34.
Haidara MA, Yassin HZ, Rateb M., et al. Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmacol. 2006;4:215-227.
35.
Giannini D. , Leone A., Di Bisceglie D., et al. The effects of acute passive smoking exposure on endothelium-dependent brachial artery dilation in healthy individuals . Angiology. 2007;58:211-217.
