The authors describe a child whose H. influenzae menin gitis persisted despite relatively high-dose ampicillin ther apy. They raise the question whether longterm morbidity from H. influenzae meningitis may be greater with ampicil lin than with the older chloramphenicol-penicillin treatment. Two experts were asked to discuss this question in the light of this case report. Their comments follow the main paper.
References
1.
Mathies, A.W. , Jr. et al.: Experience with ampicillin in bacterial meningitis. Antimicrobial Agents and Chemotherapy5: 610, 1965.
2.
Young, L.M., Haddow, J.E. and Klein, J.O.: Relapse following acute hemophilus influenza meningitis. Pediatrics41: 516, 1968.
3.
Cherry, J.D. and Sheenan, C.P.: Bacteriologic relapse in hemophilus influenzae meningitis. New Eng. J. Med.278: 1001, 1968 .
4.
Sanders, D.Y. and Garbee, H.W.: Failure of response to ampicillin in hemophilus influenzae meningitis. Am. J. Dis. Child.117: 331, 1969 .
5.
Gold, A.J., Lieberman, E. and Wright, H.T.: Bacteriologic relapse during ampicillin treatment of hemophilus influenzae meningitis. J. Pediatr.74: 779, 1969.
6.
Coleman, S.J. , Auld, E.B., Connor , J.D., Rose-man, S.B. and Warren, G.H.: Relapse of hemophilus influenzae type B meningitis. Ibid.74: 781, 1969.
7.
Levine, M.S. et al.: Recrudescence of H. influenzae meningitis after therapy with ampicillin. Clin. Pediatr. 9: 54, 1970.
8.
Greene, H.L. : Failure of ampicillin in meningitis (letter to the editor). Lancet1: 861, 1968.
9.
Thrupp, L.D. et al.: Ampicillin levels in the cerebrospinal fluid during treatment of bacterial meningitis. Antimicrobial Agents and Chemotherapy1965, p. 206.
10.
Fleming, P.C. et al.: Ampicillin in the treatment of bacterial meningitis. Antimicrobial Agents and Chemotherapy1966, p. 47.
11.
Society for Pediatric Research (Abstract). Atlantic City, New Jersey, 1970.