Abstract
Answer B. Loss of skeletal muscle mass due to inadequate protein intake
Rapid weight loss with glucagon-like peptide 1 receptor agonists, particularly in older or sedentary patients, increases the risk of sarcopenia, especially when calorie intake is very low and protein intake is insufficient. Muscle loss contributes to weakness, fatigue and functional decline and is not prevented by weight loss alone. While dehydration and micronutrient deficiencies may coexist, the dominant driver of proximal weakness and reduced physical function is loss of lean muscle mass, highlighting the importance of adequate protein intake and resistance-based activity alongside pharmacotherapy.
InnovAiT article: Beyond the prescription: A holistic GP approach to obesity and weight loss medications. DOI: 10.1177/17557380261420769.