The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography.
Design:
Subjects included eight men with NSCLP compared with six healthy control men. By using radioactively labeled water (O15), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story.
Results:
During each of the reading conditions, NSCLP subjects compared with healthy controls showed increased blood flow in areas previously reported to be involved in language processing and reading (inferior frontal lobe, cerebellum, and occipital lobe). The increased blood flow suggests a possible neural inefficiency. In contrast, when analyzing the brain regions involved in more complex language functioning (reading stories compared with reading only words), control subjects showed an increase in blood flow in a distributed neural circuit, whereas the NSCLP subjects showed a decrease in flow in these regions. Additionally, the NSCLP subjects had activation of several regions not activated in the healthy controls, suggesting a compensatory circuit used for this more complex reading task.
Conclusions:
These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading.
AndreasenN.C., ArndtS., SwayzeVII, CizadloT., FlaumM., O'LearyD., EhrhardtJ.C., YuhW.T.. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging.Science.1994; 266: 294–298.
2.
AndreasenN.C., O'LearyD.S., CizadloT., ArndtS., RezaiK., PontoL.L., WatkinsG.L., HichwaR.D.. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.Proc Natl Acad Sci U S A.1996; 93: 9985–9990.
3.
ArndtS., CizadloT., AndreasenN.C., HeckelD., GoldS., O'LearyD.S.. Tests for comparing images based on randomization and permutation methods.J Cereb Blood Flow Metab.1996; 16: 1271–1279.
4.
CizadloT., AndreasenN.C., ZeienG., RajarethinamR., HarrisG., O'LearyD., SwayzeV., ArndtS., HichwaR., EhrhardtJ., YuhW.T.. Image registration issues in the analysis of multiple-injection 15O H2O PET studies: BRAINFIT. In: Proceedings of SPIE—The International Society for Optical Engineering.Newport Beach, CA: SPIE; 1994; 2168: 234–245.
5.
DumR.P., StrickP.L.. An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex.J Neurophysiol.2003; 89: 634–639.
6.
EliasonM.. Neuropsychological perspectives of cleft lip and palate. In: BardachJ., MorrisH., eds. Multidisciplinary Management of Cleft Lip and Palate.Philadelphia: WB Saunders;1990: 825–831.
7.
FulbrightR.K., JennerA.R., MenclW.E., PughK.R., ShaywitzB.A., ShaywitzS.E., FrostS.J., SkudlarskiP., ConstableR.T., LacadieC.M., MarchioneK.E., GoreJ.C.. The cerebellum's role in reading: a functional MR imaging study.AJNR Am J Neuroradiol.1999; 20: 1925–1930.
8.
HooverJ.E., StrickP.L.. The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1.J Neurosci.1999; 19: 1446–1463.
9.
HurtigR.R., HichwaR.D., O'LearyD.S., Boles PontoL.L., NarayanaS., WatkinsG.L., AndreasenN.C.. Effects of timing and duration of cognitive activation in [15O]water PET studies.J Cereb Blood Flow Metab.1994; 14: 423–430.
10.
LancasterJ.L., SummerlnJ.L., RaineyL., FreitasC.S., FoxP.T.. The Talairach Daemon, a database server for Talairach Atlas Labels.Neuroimage.1997; 5: S633.
11.
MagnottaV.A., HarrisG., AndreasenN.C., O'LearyD.S., YuhW.T., HeckelD.. Structural MR image processing using the BRAINS2 toolbox.Comput Med Imaging Graph.2002; 26: 251–264.
12.
MechelliA., FristonK.J., PriceC.J.. The effects of presentation rate during word and pseudoword reading: a comparison of PET and fMRI.J Cogn Neurosci.2000; 12(Suppl 2): 145–156.
NopoulosP., BergS., CanadyJ., RichmanL., Van DemarkD., AndreasenN.C.. Abnormal brain morphology in adult males with isolated clefts of the lip and/or palate: a preliminary analysis.Cleft Palate Craniofac J.2000; 37: 441–446.
17.
NopoulosP., BergS., CanadyJ., RichmanL., VanDemarkD., AndreasenN.C.. Increased incidence of a midline brain anomaly in adult males with non-syndromic clefts of the lip and/or palate.J Neuroimaging.2001; 11: 1–7.
18.
NopoulosP., BergS., CanadyJ., RichmanL., VanDemarkD., AndreasenN.C.. Structural brain abnormalities in adult males with clefts of the lip and/or palate.Genet Med.2002a; 4: 1–9.
19.
NopoulosP., BergS., VanDemarkD., RichmanL., CanadyJ., AndreasenN.C.. Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate.Neuropsychologia.2002b; 40: 2178–2184.
20.
PapathanassiouD., EtardO., MelletE., ZagoL., MazoyerB., Tzourio-MazoyerN.. A common language network for comprehension and production: a contribution to the definition of language epicenters with PET.Neuroimage.2000; 11: 347–357.
21.
PetersenS.E., FoxP.T., PosnerM.I., MintunM., RaichleM.E.. Positron emission tomographic studies of the processing of single words.J Cogn Neurosci.1989; 1: 153–170.
22.
PughK.R., MenclW.E., JennerA.R., KatzL., FrostS.J., LeeJ.R., ShaywitzS.E., ShaywitzB.A.. Functional neuroimaging studies of reading and reading disability (developmental dyslexia).Ment Retard Dev Disabil Res Rev.2000; 6: 207–213.
23.
RaichleM.E., MartinW.R., HerscovitchP., MintunM.A., MarkhamJ.. Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.J Nucl Med.1983; 24: 790–798.
24.
RichmanL.C., EliasonM.J., LindgrenS.D.. Reading disability in children with clefts.Cleft Palate J.1988; 25: 21–25.
25.
RichmanL.C., RyanS.. Do the reading disabilities of children with cleft fit into current models of developmental dyslexia?Cleft Palate Craniofac J.2003; 40: 154–157.
26.
SchmahmannJ.D., PandyaD.N.. The cerebrocerebellar system.Int Rev Neurobiol.1997; 41: 31–60.
27.
ShaywitzS.E., ShaywitzB.A., PughK.R., FulbrightR.K., ConstableR.T., MenclW.E., ShankweilerD.P., LibermanA.M., SkudlarskiP., FletcherJ.M., KatzL., MarchioneK.E., LacadieC., GatenbyC., GoreJ.C.. Functional disruption in the organization of the brain for reading in dyslexia.Proc Natl Acad Sci U S A.1998; 95: 2636–2641.
28.
StanleyG., SmithG.A., HowellE.A.. Eye-movements and sequential tracking in dyslexic and control children.Br J Psychol.1983; 74: 181–187.
29.
TalairachJ., TournouxP.. Co-planar Stereotaxic Atlas of the Human Brain.New York: Thieme Medical;1988.
30.
TsukiuraT., FujiiT., TakahashiT., XiaoR., InaseM., IijimaT., YamadoriA., OkudaJ.. Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study.Brain Res Cogn Brain Res.2001; 11: 13–21.
