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Limited evidence exists to guide travelers about blood pressure (BP) changes at high altitude (HA). Our primary objective compared 24-h ambulatory BP at low altitude (LA) vs HA in a cohort of tourists. Exploratory analyses compared results by sex and history of underlying hypertension.
This prospective observational cohort study measured ambulatory BP with Welch-Allyn ABPM 6100 monitors at LA (<1000 m) and HA (median 2751 m). Measurements included heart rate/BP every 30 min while awake and hourly overnight, BP≥180/100 mm Hg, sleep quality, and Lake Louise score (acute mountain sickness).
Among 33 participants (median age 61 y, 17 with hypertension, 12 on BP medication), 25 completed LA and HA measurements. Average 24-h mean arterial pressure (MAP) increased at HA by 6 mm Hg (95% CI, 2–10 mm Hg;
Among this tourist cohort, we observed an increase in average 24-h MAP at HA. Altitude-related changes in BP varied greatly between individuals. This variation was related in part to underlying hypertension but not sex. Our data suggest that BP changes are not of clinical concern in HA travelers.
Accidental hypothermia increases mortality in patients with traumatic injury, making hypothermia management essential in prehospital trauma care. Chemical heat blankets are commonly used for this purpose. These blankets require time to get warm, with agitation often used to accelerate the exothermic reaction. Many search and rescue teams use chemical heat blankets, but optimal activation of the blankets remains uncertain. This study investigated how varying oxygen exposure durations affect the thermal performance of these blankets to guide their optimal use in search and rescue scenarios.
In room-temperature conditions, a full-body manikin was wrapped in a standardized hypothermia model, including a chemical heat blanket, and evaluated under 3 conditions: 1) no shaking, 2) shaking for 2 min, and 3) shaking for 15 min before wrapping. Thermometers were placed inside the heating panel pockets and secured in place with tape to ensure consistent measurements. Temperature data were collected over 6 h, and each scenario was performed 4 times.
Blankets shaken for 2 min achieved higher initial temperatures than those not shaken, with a significant difference sustained for 88 min. Shaking for 15 min resulted in higher initial temperatures than 2-min shaking, with no long-term difference. All scenarios converged to the same temperature (36°C) after 6 h.
Shaking the blanket for 2 min significantly improved early heating performance, whereas longer shaking offered minimal benefit. These findings suggest that short preparation time may be adequate in optimizing thermal delivery and reducing the time to treatment for patients with prehospital accidental hypothermia.
Climbing chalk is widely used by rock climbers and athletes to improve grip. It has been observed that climbers sometimes apply magnesium carbonate chalk to small wounds to stop bleeding, suggesting that climbing chalk may exhibit hemostatic properties useful for small cuts and scrapes. This study aimed to investigate and compare the effects of different types of climbing chalk on prothrombin time (PT) and activated partial thromboplastin time (aPTT).
Three types of climbing chalk were randomly selected for comparative analysis of hemostatic properties, with talcum powder used as a negative control. PT and aPTT testing were conducted on normal plasma samples containing varying concentrations of climbing chalk (from 0.125 mg/mL to 4 mg/mL). Statistical analyses of the results were performed using two-tailed t-tests, Welch's analysis of variance (ANOVA), and Games-Howell post-hoc analysis.
Results indicated that climbing chalk had no significant effect on PT but did significantly reduce aPTT compared to the negative control. Additional analyses revealed significant differences in aPTT results between different types of chalk and between higher and lower concentrations of chalk.
Magnesium carbonate-based climbing chalks appear to have a procoagulant effect on hemostasis, likely by affecting the intrinsic pathway of the coagulation cascade. While further research is needed to better understand its coagulative properties, climbing chalk shows potential as a hemostatic agent for minor wounds in wilderness medicine.
The Texas coral snake,
We reviewed all human coral snake bites reported to the Texas Poison Center Network between January 2000 and December 2023. We excluded informational calls and cases in which the snake responsible for the bite was not confirmed as
There were 501 human bites. In 472 (94.2%) cases, symptoms were limited to pain and paresthesias. Systemic toxicity, for example, weakness, dysphagia, and ptosis, was observed in 18 (3.6%) patients. Eleven (2.2%) patients had no clinical findings. Antivenom was administered in 126 (25.1%) cases. Antivenom use decreased over time; in the 5-year period from 2000–2007, antivenom was administered to 74 (55.6%) patients. Conversely, only 8 (4.1%) of patients from 2016–2023 received antivenom. Systemic findings were observed in 13 (6.5%) cases in Northeast and Central Texas compared to 5 (1.6%) in Southeast and South Texas.
Mount Aconcagua (6961 m) is the highest peak in the Americas, and thousands of climbers attempt to climb it annually. This study aimed to characterize recent climber mortality on Aconcagua to aid in future safety efforts.
Climber fatalities from Aconcagua for the 10 most recent climbing seasons (2013–2024) were retrospectively reviewed.
Over the study period, 21 of 29,397 climbers died, yielding a fatality rate of 0.071% (0.71 per 1000). Most fatalities occurred at over 6000 m (90%) and were of unspecified medical cause (71%). Trauma represented 19% of deaths. Climbers older than 50 y were more than 5 times more likely to die on Aconcagua than those younger than 50 y (odds ratio = 5.11). Climbers from the United States were found to have a higher incidence of fatality (odds ratio = 2.56). Compared with 2001-2012, fatalities from 2013-2024 occurred with similar incidence overall but more frequently at elevations over 6000 m, and victims were older and more frequently from North America.
Despite the fatality rate on Aconcagua remaining unchanged at 0.071% during 2013-2024, the percentages of deaths at over 6000 m and from medical causes increased from a prior study. Climbers older than 50 y and climbers from the United States were found to be at higher risk of death on Aconcagua. This information can provide a basis for education to reduce future mortality.
Cold-water immersion is the standard of care for treating exertional heatstroke (EHS). The Polar Life Pod (PLP; Polar Products Inc, Stow, OH), a body-bag-like device, is a novel, portable cold-water immersion device with excellent cooling rates (>0.18°C·min–1) when 151 to 208 L of water are used to treat hyperthermia. Unfortunately, these water volumes are not always available to treat EHS (eg, wilderness firefighting). Little research has examined whether the PLP with small water volumes meets expert recommendations for acceptable (ie, 0.08–0.15°C·min–1) or ideal cooling rates (ie, >0.16°C·min–1).
Thirty-two subjects (20 males and 12 females aged 21±2 y with a mass of 72.2±11.0 kg and a height of 170.4±7.2 cm) were assigned to 1 of 4 groups in this matched-pairs laboratory study. Participants wore a uniform and 9.5-kg rucksack and marched in the heat (wet-bulb globe temperature=26.1±0.1°C) until their rectal temperature (
By design, all groups had comparable physical characteristics: body fat percentage (
PLP with 76 L met expert recommendations for ideal cooling rates; 19 and 38 L demonstrated acceptable cooling rates. PLP may help save lives from EHS when water access is limited.
Ski patrollers face unique occupational risks and may be exposed to traumatic events. This study aimed to determine the relationship between traumatic event exposures and wellbeing among a cohort of U.S. ski patrollers.
A non-experimental, descriptive, longitudinal design was followed to complete a pilot study. An online survey was employed with repeated measures (1, 2, & 3 months). Participants were conveniently sampled from one ski resort in the Western United States. This study was informed by the stress continuum model.
A total of 29 participants completed at least one follow-up survey and were included as the analytic sample. Participants were primarily White (
Findings underscore the need for additional research to identify the most effective ways to support the wellbeing and resilience of ski patrollers.
Avalanches and tree-wells (TW) are causes of snow immersion death in skiers and snowboarders. TW burials may have different victim physiology profiles and rescue considerations than avalanche-related burials due to snow density, burial position, and compensatory physiologic responses. This study aimed to compare the physiological responses between avalanche and TW burials through a prospective controlled trial of simulated avalanche burial to simulated TW burial.
Eleven volunteers participated in two paired 60-min snow burials: Avalanche and TW simulations, controlling for position and snowpack densities. We monitored core temperature, respiratory rate, minute ventilation, end-tidal carbon dioxide, oxygen saturation, partial pressure of inspired carbon dioxide, and heart rate.
The average cooling rate for the avalanche simulation was −0.017(Δ°C/min) versus −0.012(Δ°C/min) for the TW simulation (
Simulated TW burial resulted in a statistically significant slower rate of core temperature cooling and earlier hypoxemia. Inverted body position in TW burials may lead to increased physiologic distress and contribute to earlier hypoxia. These findings may have important implications for search and rescue as well as resuscitation efforts for snow burial victims.
Extensor mechanism injuries and multiligamentous knee injuries are rare and typically are caused by high-energy injury mechanisms. We present a case of an active-duty military service member who sustained a patellar tendon rupture with concomitant multiligamentous knee injury due to a fall while bouldering. This case report is the first to highlight this significant injury due to bouldering, in addition to the surgical steps taken to get the patient fit for full military duty. These injuries often go undiagnosed and are incredibly important to recognize given the importance of prompt evaluation and ultimate surgical care in these scenarios.
Anterior glenohumeral joint (shoulder) dislocations are common orthopedic injuries that require timely recognition and effective reduction to prevent long-term complications. Traditional reduction techniques are typically performed on land where inherent mechanical advantage is present. This case study explores a novel in-water, prehospital technique used to reduce a shoulder dislocation during a high surf event in San Diego, California. The case involves a 36-year-old male who sustained an anterior shoulder dislocation while surfing. After initial reduction attempts using commonly described techniques were unsuccessful due to an inability to achieve adequate leverage while afloat, an improvised reduction technique was implemented, which successfully reduced the joint while floating on the ocean surface. The novel maneuver and subsequent clinical course are outlined in this case report. This technique has applications in neutral buoyancy or low-gravity environments in which the typical reduction maneuvers that require gravity or friction as leverage may not be feasible.
Autopsy surgeons routinely encounter cases involving alleged use of poison. Many of these cases are due to poisonous plant species that grow wildly in different regions of the world and are readily accessible to the general population.
Snakebites are a critical health issue in remote regions of the Amazon basin. I report a case of
A middle-aged male was admitted to the clinic 4 d after ingestion of wild mushrooms. His medical history included type 2 diabetes, hypertension, and coronary bypass. Initially misdiagnosed with infectious enterocolitis, the patient was treated as an outpatient with intravenous fluids while continuing his chronic medications (i.e., statins, beta-blockers, and aspirin). On Day 3, blood tests confirmed hepatorenal syndrome, and the patient was transferred to the clinic. On admission, he was alert with a blood pressure of 100/60 mmHg, heart rate of 100 beats/min, sinus rhythm, right upper quadrant pain, and jaundice. Lab results showed thrombocytopenia, severe hepatorenal dysfunction, prolonged prothrombin time (29.3 s), and a Model for End-Stage Liver Disease score of 30. For 3 d, the patient was simultaneously exposed to amatoxin and chronic cardiovascular medications, both substrates for the same transporters. Treatment was adjusted to intravenous acetylcysteine (double regimen), oral silymarin (600 mg/d), and supportive therapy. The patient recovered within 10 d, with transaminases normalizing after 3 mo. Understanding transporter-related drug interactions and patient-specific metabolic differences may improve future management strategies and patient survival. Further research is needed on alternative inhibitors of amatoxin uptake and competitive organic anion-transporting polypeptide substrates to expand treatment options.
Austere environments present unique challenges concerning the prevention and treatment of exertional heat-illness patients that may greatly increase the risks of morbidity and mortality. For athletes, occupational groups, and others who may work, train, or compete in austere environments, proper preparation and planning may be lifesaving. The roles of acclimatization and hydration are often emphasized in the literature, but other important risk factors may be overlooked. Work capacity, especially aerobic work capacity, will always be reduced in hot environments, and individuals should understand that simply slowing down, to reduce metabolic heat production, can be considered the universal precaution to mitigate heat stress and strain. Conversely, appropriate rehydration alone does not mitigate other risk factors, such as metabolic heat production, high ambient temperature, or inadequate physical fitness. Risk factor-specific mitigation recommendations are provided, and areas where additional research is needed are identified. The ability to recognize the signs and symptoms of heat illness early in the progression of illness is especially important in austere environments due to the possibility of delayed access to higher levels of medical care. Treatment considerations in austere environments include knowledge of availability and effectiveness of cooling modalities such as natural bodies of water. Medications such as antipyretics, dantrolene, and nonsteroidal anti-inflammatory drugs are not recommended to treat a suspected heat casualty. Aggressive cooling, with the objective of reducing core temperature to <39°C within 30-min, is the treatment priority.
Climate change contributes to warm, dry conditions, which leads to longer and more active fire seasons. Wildland firefighters work long hours in smoky conditions without regulations requiring respiratory protection. Wildfire smoke has many toxic components, including high levels of fine particulate matter (PM2.5). Regular monitoring for short- and long-term health outcomes in wildland firefighter populations is uncommon. However, extrapolating from knowledge about the individual components of smoke, it is likely that the firefighters’ health is negatively affected. Firefighters are routinely exposed to dangerous levels of smoke, which may lead to both acute and chronic health consequences. Current guidelines from Occupational Safety and Health Administration (OSHA), the U.S. Forest Service (USFS), and the Interagency Standards for Fire and Fire Aviation Operations do not recommend respirator use for wildland firefighters. The methodologies used to quantify exposure and harm likely underestimate actual risks. Although there are no respirators that can filter all known harmful components of wildfire smoke, this review examines the potential benefit of respirator use by reducing some of the most harmful components of the smoke. Smoke exposure among wildland firefighters needs to be further characterized and quantified. Regulations should be reassessed to accurately reflect the exposure and potential harm that firefighters face. This narrative review gathers information from peer-reviewed scientific literature, government publications, news articles, and personal conversations with both public- and private-sector professionals. The objectives are to describe the likely health effects of wildland firefighting, evaluate the evidence behind current respiratory protection guidelines, and propose potential solutions.
Trail running is an endurance sport that entails running outdoors on natural terrain. Scientific literature provides minimal information on serious adverse events that occur during trail running. The objectives of this review were to identify and summarize the available information published in online worldwide news articles and to categorize the results in fatal, missing, and catastrophic events in trail running. Over a 14-wk period, online news articles were searched using Google Advanced Search and DuckDuckGo for reports on serious adverse events during trail running. Data were extracted and summarized from online news articles that met the inclusion criteria. Ninety-four online news articles reported on 127 runners involved in serious adverse events during trail running. Among the serious adverse events reported in this review, 82% (n = 104) were fatal trail running events; 29% (n = 37) were related to missing events, of which 54% (n = 20) of the missing events resulted in death; and 6% (n = 6) were catastrophic injuries. Most runners were males (73%) aged 16 to 75 y (41.5 ± 12.6 y). The most common intrinsic causes of death were cardiac arrest (58%) and collapse (38%), whereas the most common extrinsic causes of death were cold weather resulting in potential hypothermia (40%) and blunt trauma following falling/slipping (25%). Almost half the runners who went missing (41%) were found. The 6 runners involved in catastrophic events (6%) suffered severe burn wounds, brain damage, and frostbite. Serious adverse events in trail running seem to be rare. This review reports multiple serious adverse events during trail running. Although these events are rare, they highlight the need for further research and improved reporting. These findings can assist in developing future prevention strategies for trail running events and guide medical staff during race-day medical planning.
During combat with German Nazis in the deserts of North Africa, it became imperative for the United States Army to research to ascertain the physiological limits of military ground troops subjected to extreme desert heat exposure. In the 1940s, Edward F. Adolph, PhD, from the University of Rochester School of Medicine & Dentistry (URSMD), was funded through a contract with the government to initiate research on human tolerance to the extremes of desert heat. Consequently, Adolph and his associates established the university's Desert Research Unit in the California desert. In the 1930s, a team from Harvard University's Fatigue Laboratory established the “Harvard Desert Expedition” for field research in the Nevada desert. Notably, both Harvard and Rochester research teams investigated human metabolic responses in desert heat, with Dr Adolph participating in both desert locations. These field studies were conducted during Adolph's time as a faculty member in the Department of Physiology at the URSMD, which spanned over 62 years. Adolph's research interests encompassed investigations into the physiological responses of humans in desert environments, including regulation of water and heat metabolism, sweat formation, dehydration, thirst, physiological adaptations to extreme heat, and survival without water. Adolph authored or co-authored a substantial body of work, including 155 articles and 4 books, culminating in the seminal text



